Pesquisa | Secretaria de Estado da Saúde

1.

Hypoxia and Innate Immunity: Keeping Up with the HIFsters.

Colgan, Sean P; Furuta, Glenn T; Taylor, Cormac T.

Annu Rev Immunol ; 38: 341-363, 2020 04 26.

Artigo Inglês | MEDLINE | ID: mdl-31961750

2.

Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism.

Meisel, Joshua D; Miranda, Maria; Skinner, Owen S; Wiesenthal, Presli P; Wellner, Sandra M; Jourdain, Alexis A; Ruvkun, Gary; Mootha, Vamsi K.

Cell ; 187(3): 659-675.e18, 2024 Feb 01.

Artigo Inglês | MEDLINE | ID: mdl-38215760

3.

Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion.

Yan, Ronghui; Zhang, Pinggen; Shen, Shengqi; Zeng, Yu; Wang, Ting; Chen, Zhaolin; Ma, Wenhao; Feng, Junru; Suo, Caixia; Zhang, Tong; Wei, Haoran; Jiang, Zetan; Chen, Rui; Li, Shi-Ting; Zhong, Xiuying; Jia, Weidong; Sun, Linchong; Cang, Chunlei; Zhang, Huafeng; Gao, Ping.

Nat Immunol ; 25(3): 483-495, 2024 Mar.

Artigo Inglês | MEDLINE | ID: mdl-38177283

4.

Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity.

Vignali, Paolo D A; DePeaux, Kristin; Watson, McLane J; Ye, Chenxian; Ford, B Rhodes; Lontos, Konstantinos; McGaa, Nicole K; Scharping, Nicole E; Menk, Ashley V; Robson, Simon C; Poholek, Amanda C; Rivadeneira, Dayana B; Delgoffe, Greg M.

Nat Immunol ; 24(2): 267-279, 2023 02.

Artigo Inglês | MEDLINE | ID: mdl-36543958

5.

Depletion of slow-cycling PDGFRα⁺ADAM12⁺ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis.

Di Carlo, Selene E; Raffenne, Jerome; Varet, Hugo; Ode, Anais; Granados, David Cabrerizo; Stein, Merle; Legendre, Rachel; Tuckermann, Jan; Bousquet, Corinne; Peduto, Lucie.

Nat Immunol ; 24(11): 1867-1878, 2023 Nov.

Artigo Inglês | MEDLINE | ID: mdl-37798557

6.

Every Breath You Take: New Insights into Plant and Animal Oxygen Sensing.

Gibbs, Daniel J; Holdsworth, Michael J.

Cell ; 180(1): 22-24, 2020 01 09.

Artigo Inglês | MEDLINE | ID: mdl-31785834

7.

Oxygen Sensing: After the Nobel.

Cell ; 180(1): 7-8, 2020 01 09.

Artigo Inglês | MEDLINE | ID: mdl-31951521

8.

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism.

Jain, Isha H; Calvo, Sarah E; Markhard, Andrew L; Skinner, Owen S; To, Tsz-Leung; Ast, Tslil; Mootha, Vamsi K.

Cell ; 181(3): 716-727.e11, 2020 04 30.

Artigo Inglês | MEDLINE | ID: mdl-32259488

9.

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation.

Mirchandani, Ananda S; Jenkins, Stephen J; Bain, Calum C; Sanchez-Garcia, Manuel A; Lawson, Hannah; Coelho, Patricia; Murphy, Fiona; Griffith, David M; Zhang, Ailiang; Morrison, Tyler; Ly, Tony; Arienti, Simone; Sadiku, Pranvera; Watts, Emily R; Dickinson, Rebecca S; Reyes, Leila; Cooper, George; Clark, Sarah; Lewis, David; Kelly, Van; Spanos, Christos; Musgrave, Kathryn M; Delaney, Liam; Harper, Isla; Scott, Jonathan; Parkinson, Nicholas J; Rostron, Anthony J; Baillie, J Kenneth; Clohisey, Sara; Pridans, Clare; Campana, Lara; Lewis, Philip Starkey; Simpson, A John; Dockrell, David H; Schwarze, Jürgen; Hirani, Nikhil; Ratcliffe, Peter J; Pugh, Christopher W; Kranc, Kamil; Forbes, Stuart J; Whyte, Moira K B; Walmsley, Sarah R.

Nat Immunol ; 23(6): 927-939, 2022 06.

Artigo Inglês | MEDLINE | ID: mdl-35624205

10.

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.

Ast, Tslil; Meisel, Joshua D; Patra, Shachin; Wang, Hong; Grange, Robert M H; Kim, Sharon H; Calvo, Sarah E; Orefice, Lauren L; Nagashima, Fumiaki; Ichinose, Fumito; Zapol, Warren M; Ruvkun, Gary; Barondeau, David P; Mootha, Vamsi K.

Cell ; 177(6): 1507-1521.e16, 2019 05 30.

Artigo Inglês | MEDLINE | ID: mdl-31031004

11.

Physiological and Genetic Adaptations to Diving in Sea Nomads.

Ilardo, Melissa A; Moltke, Ida; Korneliussen, Thorfinn S; Cheng, Jade; Stern, Aaron J; Racimo, Fernando; de Barros Damgaard, Peter; Sikora, Martin; Seguin-Orlando, Andaine; Rasmussen, Simon; van den Munckhof, Inge C L; Ter Horst, Rob; Joosten, Leo A B; Netea, Mihai G; Salingkat, Suhartini; Nielsen, Rasmus; Willerslev, Eske.

Cell ; 173(3): 569-580.e15, 2018 04 19.

Artigo Inglês | MEDLINE | ID: mdl-29677510

12.

Take my breath away: TAM-ing anti-cancer immunity in hypoxic niches.

Möckl, Aylin; Sevenich, Lisa.

Immunity ; 56(8): 1704-1706, 2023 08 08.

Artigo Inglês | MEDLINE | ID: mdl-37557077

13.

Hypoxia prevents premature ageing in mice.

Strzyz, Paulina.

Nat Rev Mol Cell Biol ; 24(8): 522, 2023 08.

Artigo Inglês | MEDLINE | ID: mdl-37291386

14.

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.

Mantel, Charlie R; O'Leary, Heather A; Chitteti, Brahmananda R; Huang, XinXin; Cooper, Scott; Hangoc, Giao; Brustovetsky, Nickolay; Srour, Edward F; Lee, Man Ryul; Messina-Graham, Steven; Haas, David M; Falah, Nadia; Kapur, Reuben; Pelus, Louis M; Bardeesy, Nabeel; Fitamant, Julien; Ivan, Mircea; Kim, Kye-Seong; Broxmeyer, Hal E.

Cell ; 161(7): 1553-65, 2015 Jun 18.

Artigo Inglês | MEDLINE | ID: mdl-26073944

15.

A lactate-induced response to hypoxia.

Lee, Dong Chul; Sohn, Hyun Ahm; Park, Zee-Yong; Oh, Sangho; Kang, Yun Kyung; Lee, Kyoung-Min; Kang, Minho; Jang, Ye Jin; Yang, Suk-Jin; Hong, Young Ki; Noh, Hanmi; Kim, Jung-Ae; Kim, Dong Joon; Bae, Kwang-Hee; Kim, Dong Min; Chung, Sang J; Yoo, Hyang Sook; Yu, Dae-Yeul; Park, Kyung Chan; Yeom, Young Il.

Cell ; 161(3): 595-609, 2015 Apr 23.

Artigo Inglês | MEDLINE | ID: mdl-25892225

16.

BMAL1 drives muscle repair through control of hypoxic NAD⁺ regeneration in satellite cells.

Zhu, Pei; Hamlish, Noah X; Thakkar, Abhishek Vijay; Steffeck, Adam W T; Rendleman, Emily J; Khan, Nabiha H; Waldeck, Nathan J; DeVilbiss, Andrew W; Martin-Sandoval, Misty S; Mathews, Thomas P; Chandel, Navdeep S; Peek, Clara B.

Genes Dev ; 36(3-4): 149-166, 2022 02 01.

Artigo Inglês | MEDLINE | ID: mdl-35115380

17.

Systemic hypoxia drives inflammation persistence via suppression of monocytes.

Nat Immunol ; 23(6): 830-831, 2022 06.

Artigo Inglês | MEDLINE | ID: mdl-35654850

18.

A breath of fresh macrophages ameliorates inflammation in the hypoxic lung.

De Ponti, Federico F; Scott, Charlotte L.

Nat Immunol ; 23(6): 820-822, 2022 06.

Artigo Inglês | MEDLINE | ID: mdl-35624203

19.

Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors.

Croci, Diego O; Cerliani, Juan P; Dalotto-Moreno, Tomas; Méndez-Huergo, Santiago P; Mascanfroni, Ivan D; Dergan-Dylon, Sebastián; Toscano, Marta A; Caramelo, Julio J; García-Vallejo, Juan J; Ouyang, Jing; Mesri, Enrique A; Junttila, Melissa R; Bais, Carlos; Shipp, Margaret A; Salatino, Mariana; Rabinovich, Gabriel A.

Cell ; 156(4): 744-58, 2014 Feb 13.

Artigo Inglês | MEDLINE | ID: mdl-24529377

20.

Uncovering the Ediacaran phosphorus cycle.

Dodd, Matthew S; Shi, Wei; Li, Chao; Zhang, Zihu; Cheng, Meng; Gu, Haodong; Hardisty, Dalton S; Loyd, Sean J; Wallace, Malcolm W; vS Hood, Ashleigh; Lamothe, Kelsey; Mills, Benjamin J W; Poulton, Simon W; Lyons, Timothy W.

Nature ; 618(7967): 974-980, 2023 Jun.

Artigo Inglês | MEDLINE | ID: mdl-37258677

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